MD TP20: Signaling in neutrophils induced by IgG subclasses

The key contribution of Fc gamma receptors expressed by neutrophils to autoantibody-induced tissue damage (blistering) in experimental models of autoimmune bullous dermatoses (AIBDs) has been well documented (Trends Mol Med, 2013). The importance for blister formation in experimental epidermolysis bullosa acquisita (EBA) of the release of effector molecules from activated neutrophils has also been well documented. Events linking Fc gamma receptor initiated activation and mediator release from neutrophils are, however, far from being completely understood. Therefore this project aims to investigate these events in detail.