MD TP17: Modulation of pemphigoid disease by keratinocyte-derrived lipid mediators

In pemphigoid disease, binding of autoantibodies to the target antigens expressed on kerationcytes can trigger a biologic response, i.e. cytokine release (J Invest Dermatol 2000). 

Here we will investigate if keratinocytes also release bioactive lipid-mediators after the binding of the autoantibodies. We furthermore will investigate the effects of these mediators on key pathogenic events in pemphigoid disease.