MD TP10:

T cell activation is crucial for the induction of autoimmune diseases, such as autoimmune bullous dermatoses (AIBD). However, therapies targeting this crucial event have not been fully established in patients. We here will use a non-hypothesis driven approach to identify novel compounds targeting T cell activation. 

The experimental work has been completed. The daw obtained will be the basis for the thesis. The overall project is continued in MD TP10b and MD TP10c, focusing on the synergistic effects of the identified T cell inhibitory compounds, and on the in vivo validation, respectively.