Associated TP24: T cell receptor repertoire in experimental epidermolysis bullosa acquisita
Chronic inflammation in autoimmune diseases is caused by a dysregulated immune system and a loss of tolerance to autoantiges. One typical example of a chronic autoimmune disease is EBA. The clinical manifestation of EBA is characterized by the production of complement activating autoantibodies targeting type VII collagen, an integral element of the dermal-epidermal junction. Experimental studies, focusing on the development of EBA, identified CD4+ T helper cells as necessary and key contributors in EBA formation. In general, the importance of T cells in inflammation is well characterized although, information about the T cell receptor repertoire in immune-mediated disorders such as EBA is lacking. Based on the huge variety of the potential antigen receptors and subsequently T cells, an analysis of the exact adaptive immune repertoire was not feasible in the past. With ongoing development in the field of next-generation sequencing (NGS), with focus on the T cell receptors α and β chains, deep sequencing of the highly variable complementary-determining region 3 (CDR3) region was enabled.
The main goal of this project is the identification of the T cell receptor repertoire in inflammatory autoimmune diseases and to evaluate processes possibly leading to disease manifestation. In order to achieve this, the CDR 3 region of the T cell receptor β chains in germinal centers and affected skin areas is analyzed via NGS and evaluated by bioinformatic analysis. This might enable the identification of autoreactive T cell receptors, conducting the loss of tolerance.

- Projects
- Projects
- Associated projects
- MD projects
- Associated MD projects
- Concluded projects
- Concluded TP
- Concluded Ass.TP
- associated TP1 - Immunoadsorbtion
- associated TP2 - Breg
- associated TP3 - Osteoimmunology
- associated TP4 - Cytokines in EBA
- associated TP5 - Scaring alopecia
- associated TP6 - Diet and Autoimmunity
- associated TP7 - QTL in RA
- associated TP8 - Systems biology
- associated TP9 - Microbiome
- associated TP10 - Wound healing in EBA
- associated TP11 - Novel BP model
- associated TP12 - Anti-p200 pemphigoid
- associated TP13 - miRNA expression patterns
- associated TP14 - therapeutic Collagen VII and XVII-specific IgGs
- associated TP 15 - Bioactive lipid mediaters
- associated TP 17 - The role of mitochondrial DNA
- associated TP 18 -Pathogenesis of pemphigoid diseases
- associated TP 19 - New neutrophil inhibitors
- associated TP 20 - Glycosylated antibodies & autoreactive B cells
- associated TP 21 - Glycosylated IgA
- associated TP 22 - Neuronal auto-antigens
- associated TP 23 - Neuroinflammatory autoantibodies
- associated TP 24 - T cell repertoire
- associated TP 25 - Nutrition in EBA
- associated TP 26 - Circadian clocks in EBA
- associated TP 27 - Pemphigus characterization
- associated TP 28 - Mast cells in BP
- associated TP 29 - IL-10 in EBA
- Concluded MD TP
- Concluded Ass. MD TP