associated TP35: The role of IgG glycosylation in the attenuation of anaphylactic reactions

The effector function of IgG antibodies is dependent on the IgG subclass and the IgG Fc N-glycosylation pattern. Our laboratory investigates the development and function of differentially glycosylated IgG subclass antibodies.
In this project we investigate the potential of differently glycosylated IgG antibodies to attenuate IgG-mediated and IgG-controlled IgE-mediated anaphylactic reactions. As it is known that the kind of IgG glycosylation is associated with the severity of inflammatory autoimmune diseases and that IgE antibodies can also play a role in certain autoimmune diseases like systemic lupus erythematosus and bullous pemphigoid (BP), our studies might further elucidate their role in autoimmunity and give some new ideas for treatment options of autoimmune diseases.

- Epp, A., Hobusch, J., Bartsch, Y. C., Petry, J., Lilienthal, G. M., Koeleman, C. A. M., Eschweiler, S., Mobs, C., Hall, A., Morris, S. C., Braumann, D., Engellenner, C., Bitterling, J., Rahmoller, J., Leliavski, A., Thurmann, R., Collin, M., Moremen, K. W., Strait, R. T., Blanchard, V., Petersen, A., Gemoll, T., Habermann, J. K., Petersen, F., Nandy, A., Kahlert, H., Hertl, M., Wuhrer, M., Pfutzner, W., Jappe, U., Finkelman, F. D. and Ehlers, M. Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J. Allergy Clin. Immunol. 2018; 141 (1), 399-402.e8.
- Bartsch Y, Rahmöller J, Mertes MMM, Eiglmeier S, Lorenz FKM, Stoehr AD, Braumann D, Lorenz AK, Winkler A, Lilienthal G-M, Petry J, Hobusch J, Steinhaus M, Hess C, Holecska V, Schoen CT, Oefner CM, Leliavski A, Blanchard V, and Ehlers M. Sialylated autoantigen-reactive IgG antibodies attenuate disease development in autoimmune mouse models of lupus nephritis and rheumatoid arthritis. Frontiers Immunol. 2018; 9:1183.
- Lilienthal G-M, Rahmöller J, Petry J, Bartsch YC, Leliavsky A, and Ehlers M. Potential of murine IgG1 and human IgG4 to inhibit the classical complement and Fcgamma receptor activation pathways. Frontiers Immunol. 2018; 9:958
- Karsten CM, Pandey MK, Figge J, Kilchenstein R, Taylor PR, Rosas M, McDonald JU, Orr S, Berger M, Petzold D, Blanchard V, Winkler A, Hess C, Reid DM, Majoul IV, Strait RT, Harris NL, Köhl G, Wollin L, Ludwig R, Zillikens D, Nimmerjahn F, Finkelman FD, Brown GD, Ehlers M, and Köhl J. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med 2012; 18(9):1401-1406.