TP7: Role of Fc gamma receptors in the pathogenesis of experimentall bullous pemphigoid in adult mice

Bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA) are subepidermal blistering autoimmune diseases. For both disorders, the infiltration of inflammatory cells including lymphocytes, neutrophils and macrophages in the skin is essential. We have recently developed passive transfer mouse models for both BP and EBA. In these models, the injection of anti-type XVII collagen and anti-type VII collagen antibodies, respectively, in adult mice induce skin diseases that replicate the immunopathological hallmarks of the human disorders. In the present project, we want to identify the pathogenetically relevant Fc gamma R receptors (R) in experimental BP and compare the findings with data recently obtained in experimental EBA. In the first set of experiments, various Fc gamma R-deficient mice and specific Fc gamma R inhibitors will be used. In the second part of this project, we will identify the Fc gamma R-bearing cell population, neutrophils or macrophages, that is important in experimental BP.

Franziska Sophie Schulze graduated in 02/2015, the results of her work have been published here. She now works as a PostDoc in the AG Schmidt in the Lübecker Institute of experimental dermatology (LIED) and mentors GRK-projects.