TP A6: Signals leading to differentially glycosylated IgG antibodies

Our lab focuses on the effects of differently glycosylated antibodies on immune functions; e.g. Nature 2014, J Clin Invest 2013, Exp Dermatol 2013 and J Allergy Clin Immunol 2012

Here we will investigate in detail the effects of immune complexes on dendritic cells and (subsequently) T cell differentiation. In first experiments we will employ model antigens, i.e. TNP-OVA. In perspective we will test the identified principles also in the context of autoimmune disease, namely epidermolysis bullosa acquisita.