TP B1: Applied longitudinal transcriptomics of autoreactive B cells in pemphigus patients

Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two potentially life-threatening autoimmune blistering skin diseases, that are characterized by pathologic anti-desmoglein autoantibodies and autoreactive B cells that produce them.Longitudinal analyses of the transcriptomes of these autoreactive B cells before and after therapy by RNA-sequencing should allow insights into molecular pathways of the disease and the current treatments.Therefore Pathways associated with induction of remission may be exploited for testing of new, more targeted treatment strategies.