TP B6: Pathomechanisms in experimental systemic sclerosis
Systemic sclerosis (SSc) is a systemic autoimmune disorder with multiple organs involvement and heterogeneous clinical manifestations. It is characterized by fibrosis in skin and visceral organs, vasculopathy and autoimmunity. The pathogenic mechanisms of SSc is still largely unknown.
Recently, our group have developed a novel mouse model for SSc through immunizing mice with human AT1R (hAT1R). Besides generation of autoantibodies against AT1R, the hAT1R-immunized mice develop skin fibrosis and show inflammation in the skin and lung. Therefore, this mouse model provides a new research tool for investigating the pathomechanisms in SSc.
In this project, we aim to investigate the role of CD4+ T cells, CD8+ T cells and B cells in this novel mouse model of SSc.
- Projects
- Projects
- TP A1 - B cell metabolism
- TP A2 - Expression profiling based drug design in EBA
- TP A3 -Differential roles and cell type specific effects of IL-17A and IL-17F in EBA
- TP A4 - Anti-laminin 322 mucous membrane pemphigoid
- TP A5 - C5a/C5aR in autoantibody induction
- TP A6 - Effects of immune-complexes with sialylated IgG antibodies...
- TP A7 - The effect of neutrophil extracellular traps (NETs) on human neutrophils in vitro
- TP B1 - Novel pemphigus animal model
- TP B2 - Autoimmunity alters the T cell receptor repertoire ...
- TP B3 - Metabolomics in autoimmunity
- TP B4 - Organotropism of leukocyte migration
- TP B6 - Pathomechanisms in experimental Systemic Sclerosis
- Associated projects
- MD projects
- Associated MD projects
- Concluded projects
- Projects