TP A1: B cell metabolism in autoimmunity
In recent years, changes in metabolism have been shown to influence the differentiation of T cells and monocytes/macrophages into pro- or anti-inflammatory subsets. Moreover, nutrition drastically influences autoimmune inflammation. Current concepts suggest that targeting metabolic pathways could represent a novel therapeutic strategy. Though not well studied so far, growing evidence is found that B cells react similarly to metabolic challenges.
This study aims to further characterise the metabolic profile of B cell subsets and the impact of certain metabolites on the differentiation of mature B cells into plasma cells or germinal centre B cells. Additionally, the influence of metabolites on the production of autoantibodies and immunomodulatory molecules such as IL-10 will be investigated. Finally, the impact of metabolites on B cells will be studied in models for autoimmune diseases, such as epidermolysis bullosa acquisita (EBA).
- Projects
- Projects
- TP A1 - B cell metabolism
- TP A2 - Expression profiling based drug design in EBA
- TP A3 -Differential roles and cell type specific effects of IL-17A and IL-17F in EBA
- TP A4 - Anti-laminin 322 mucous membrane pemphigoid
- TP A5 - C5a/C5aR in autoantibody induction
- TP A6 - Effects of immune-complexes with sialylated IgG antibodies...
- TP A7 - The effect of neutrophil extracellular traps (NETs) on human neutrophils in vitro
- TP B1 - Novel pemphigus animal model
- TP B2 - Autoimmunity alters the T cell receptor repertoire ...
- TP B3 - Metabolomics in autoimmunity
- TP B4 - Organotropism of leukocyte migration
- TP B6 - Pathomechanisms in experimental Systemic Sclerosis
- Associated projects
- MD projects
- Associated MD projects
- Concluded projects
- Projects