Associated TP11: Passive transfer model for bullous pemphigoid in adult mice

Bullous pemphigoid is one of the most common autoimmune blistering skin diseases in the elderly people  associated with autoantibodies against hemidesmosomal proteins. There are few animal models available to study this disease. Most of the studies are done in a neonatal mouse model.

Aim of this project is to develop and characterize a passive transfer animal model in adult mice using anti-type XVII collagen antibodies.  This new model should reflect better the human disease in elderly people and allow us to study new therapeutic possibilities.

Results of the project have been published (Am J Pathol, 2014) and Tina Beckmann graduated in 2014 and now works as an Inside Sales Specalist at Illumina in the UK.