RTG1727 | RTG "Modulation of Autoimmunity"

Dr. rer.nat. Lars Komorowski

Institute of Experimental Immunology, Euroimmun AG
23560 Lübeck

Email:	l.komorowski(at)euroimmun.de
Phone:	+49 4515855 23172
Fax:	+49 451 500 50888

Publications

2019

Emtenani, S., Yuan, H., Lin, C., Pan, M., Hundt, J. E., Schmidt, E., Komorowski, L., Stanley, J. R. and Hammers, C. M.: Normal human skin is superior to monkey oesophagus substrate for detection of circulating BP180-NC16A-specific IgG antibodies in bullous pemphigoid Br. J. Dermatol., vol. 180, no. 5, pp. 1099-1106, y, 2019

% 30315657 
@Article{pmid30315657,
   Author="Emtenani, S.  and Yuan, H.  and Lin, C.  and Pan, M.  and Hundt, J. E.  and Schmidt, E.  and Komorowski, L.  and Stanley, J. R.  and Hammers, C. M. ",
   Title="{{N}ormal human skin is superior to monkey oesophagus substrate for detection of circulating {B}{P}180-{N}{C}16{A}-specific {I}g{G} antibodies in bullous pemphigoid}",
   Journal="Br. J. Dermatol.",
   Year="2019",
   Volume="180",
   Number="5",
   Pages="1099--1106",
   Month="May"
}

Goletz, S., Probst, C., Komorowski, L., Schlumberger, W., Fechner, K., van Beek, N., Holtsche, M. M., Recke, A., Yancey, K. B., Hashimoto, T., Antonicelli, F., Di Zenzo, G., Zillikens, D., Stocker, W. and Schmidt, E.: A sensitive and specific assay for the serological diagnosis of antilaminin 332 mucous membrane pemphigoid Br. J. Dermatol., vol. 180, no. 1, pp. 149-156, n, 2019

% 30216412 
@Article{pmid30216412,
   Author="Goletz, S.  and Probst, C.  and Komorowski, L.  and Schlumberger, W.  and Fechner, K.  and van Beek, N.  and Holtsche, M. M.  and Recke, A.  and Yancey, K. B.  and Hashimoto, T.  and Antonicelli, F.  and Di Zenzo, G.  and Zillikens, D.  and Stocker, W.  and Schmidt, E. ",
   Title="{{A} sensitive and specific assay for the serological diagnosis of antilaminin 332 mucous membrane pemphigoid}",
   Journal="Br. J. Dermatol.",
   Year="2019",
   Volume="180",
   Number="1",
   Pages="149--156",
   Month="Jan"
}

2018

Ohst, C., Saschenbrecker, S., Stiba, K., Steinhagen, K., Probst, C., Radzimski, C., Lattwein, E., Komorowski, L., Stocker, W. and Schlumberger, W.: Reliable Serological Testing for the Diagnosis of Emerging Infectious Diseases Adv. Exp. Med. Biol., vol. 1062, pp. -43, 2018

@Article{pmid29845523,
   Author="Ohst, C.  and Saschenbrecker, S.  and Stiba, K.  and Steinhagen, K.  and Probst, C.  and Radzimski, C.  and Lattwein, E.  and Komorowski, L.  and Stocker, W.  and Schlumberger, W. ",
   Title="{{R}eliable {S}erological {T}esting for the {D}iagnosis of {E}merging {I}nfectious {D}iseases}",
   Journal="Adv. Exp. Med. Biol.",
   Year="2018",
   Volume="1062",
   Pages="19--43"
}

Emtenani, S., Yuan, H., Lin, C., Pan, M., Hundt, J. E., Schmidt, E., Komorowski, L., Stanley, J. R. and Hammers, C. M.: Normal human skin is superior to monkey esophagus substrate for detection of circulating BP180-NC16A-specific immunoglobulin G antibodies in bullous pemphigoid Br. J. Dermatol., t, 2018

% 30315657 
@Article{pmid30315657,
   Author="Emtenani, S.  and Yuan, H.  and Lin, C.  and Pan, M.  and Hundt, J. E.  and Schmidt, E.  and Komorowski, L.  and Stanley, J. R.  and Hammers, C. M. ",
   Title="{{N}ormal human skin is superior to monkey esophagus substrate for detection of circulating {B}{P}180-{N}{C}16{A}-specific immunoglobulin {G} antibodies in bullous pemphigoid}",
   Journal="Br. J. Dermatol.",
   Year="2018",
   Month="Oct"
}

Alfugham, N., Gadoth, A., Lennon, V. A., Komorowski, L., Scharf, M., Hinson, S., McKeon, A. and Pittock, S. J.: ITPR1 autoimmunity: Frequency, neurologic phenotype, and cancer association Neurol Neuroimmunol Neuroinflamm, vol. 5, no. 1, pp. e418, n, 2018

@Article{pmid29379822,
   Author="Alfugham, N.  and Gadoth, A.  and Lennon, V. A.  and Komorowski, L.  and Scharf, M.  and Hinson, S.  and McKeon, A.  and Pittock, S. J. ",
   Title="{{I}{T}{P}{R}1 autoimmunity: {F}requency, neurologic phenotype, and cancer association}",
   Journal="Neurol Neuroimmunol Neuroinflamm",
   Year="2018",
   Volume="5",
   Number="1",
   Pages="e418",
   Month="Jan"
}

Hofrichter, M., Dworschak, J., Emtenani, S., Langenhan, J., Weiss, F., Komorowski, L., Zillikens, D., Stocker, W., Probst, C., Schmidt, E. and Goletz, S.: Immunoadsorption of Desmoglein-3-Specific IgG Abolishes the Blister-Inducing Capacity of Pemphigus Vulgaris IgG in Neonatal Mice Front Immunol, vol. 9, pp. 35, 2018

% 30233569 
@Article{pmid30233569,
   Author="Hofrichter, M.  and Dworschak, J.  and Emtenani, S.  and Langenhan, J.  and Weiss, F.  and Komorowski, L.  and Zillikens, D.  and Stocker, W.  and Probst, C.  and Schmidt, E.  and Goletz, S. ",
   Title="{{I}mmunoadsorption of {D}esmoglein-3-{S}pecific {I}g{G} {A}bolishes the {B}lister-{I}nducing {C}apacity of {P}emphigus {V}ulgaris {I}g{G} in {N}eonatal {M}ice}",
   Journal="Front Immunol",
   Year="2018",
   Volume="9",
   Pages="1935"
}

2017

Mindorf, S., Dettmann, I. M., Kruger, S., Fuhrmann, T., Rentzsch, K., Karl, I., Probst, C., Komorowski, L., Fechner, K., van Beek, N., Lemcke, S., Sardy, M., Bangert, C., Benoit, S., Hashimoto, T., Zillikens, D., Pas, H. H., Jonkman, M. F., Stocker, W. and Schmidt, E.: Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus Exp. Dermatol., vol. 26, no. 12, pp. 1267-1270, 28038887, 2017

% 28815795 
@Article{pmid28815795,
   Author="Mindorf, S.  and Dettmann, I. M.  and Kruger, S.  and Fuhrmann, T.  and Rentzsch, K.  and Karl, I.  and Probst, C.  and Komorowski, L.  and Fechner, K.  and van Beek, N.  and Lemcke, S.  and Sardy, M.  and Bangert, C.  and Benoit, S.  and Hashimoto, T.  and Zillikens, D.  and Pas, H. H.  and Jonkman, M. F.  and Stocker, W.  and Schmidt, E. ",
   Title="{{R}outine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus}",
   Journal="Exp. Dermatol.",
   Year="2017",
   Volume="26",
   Number="12",
   Pages="1267--1270",
   Month="12"
}

Dettmann, I. M., Kruger, S., Fuhrmann, T., Rentzsch, K., Karl, I., Probst, C., Komorowski, L., Fechner, K., van Beek, N., Lemcke, S., Sardy, M., Bangert, C., Benoit, S., Hashimoto, T., Zillikens, D., Pas, H. H., Jonkman, M. F., Stocker, W. and Schmidt, E.: Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus Exp. Dermatol., g, 2017

@Article{pmid28815795,
   Author="Dettmann, I. M.  and Kruger, S.  and Fuhrmann, T.  and Rentzsch, K.  and Karl, I.  and Probst, C.  and Komorowski, L.  and Fechner, K.  and van Beek, N.  and Lemcke, S.  and Sardy, M.  and Bangert, C.  and Benoit, S.  and Hashimoto, T.  and Zillikens, D.  and Pas, H. H.  and Jonkman, M. F.  and Stocker, W.  and Schmidt, E. ",
   Title="{{R}outine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus}",
   Journal="Exp. Dermatol.",
   Year="2017",
   Month="Aug"
}

Chen, J., Zheng, Q., Hammers, C. M., Ellebrecht, C. T., Mukherjee, E. M., Tang, H. Y., Lin, C., Yuan, H., Pan, M., Langenhan, J., Komorowski, L., Siegel, D. L., Payne, A. S. and Stanley, J. R.: Proteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics Cell Rep, vol. 18, no. 1, pp. 237-247, 2017

% 28052253 
@Article{pmid28052253,
   Author="Chen, J.  and Zheng, Q.  and Hammers, C. M.  and Ellebrecht, C. T.  and Mukherjee, E. M.  and Tang, H. Y.  and Lin, C.  and Yuan, H.  and Pan, M.  and Langenhan, J.  and Komorowski, L.  and Siegel, D. L.  and Payne, A. S.  and Stanley, J. R. ",
   Title="{{P}roteomic {A}nalysis of {P}emphigus {A}utoantibodies {I}ndicates a {L}arger, {M}ore {D}iverse, and {M}ore {D}ynamic {R}epertoire than {D}etermined by {B} {C}ell {G}enetics}",
   Journal="Cell Rep",
   Year="2017",
   Volume="18",
   Number="1",
   Pages="237--247",
   Month="01"
}

Ludwig, R. J., Vanhoorelbeke, K., Leypoldt, F., Kaya, Z., Bieber, K., McLachlan, S. M., Komorowski, L., Luo, J., Cabral-Marques, O., Hammers, C. M., Lindstrom, J. M., Lamprecht, P., Fischer, A., Riemekasten, G., Tersteeg, C., Sondermann, P., Rapoport, B., Wandinger, K. P., Probst, C., El Beidaq, A., Schmidt, E., Verkman, A., Manz, R. A. and Nimmerjahn, F.: Mechanisms of Autoantibody-Induced Pathology Front Immunol, vol. 8, pp. 3, 2017

@Article{pmid28620373,
   Author="Ludwig, R. J.  and Vanhoorelbeke, K.  and Leypoldt, F.  and Kaya, Z.  and Bieber, K.  and McLachlan, S. M.  and Komorowski, L.  and Luo, J.  and Cabral-Marques, O.  and Hammers, C. M.  and Lindstrom, J. M.  and Lamprecht, P.  and Fischer, A.  and Riemekasten, G.  and Tersteeg, C.  and Sondermann, P.  and Rapoport, B.  and Wandinger, K. P.  and Probst, C.  and El Beidaq, A.  and Schmidt, E.  and Verkman, A.  and Manz, R. A.  and Nimmerjahn, F. ",
   Title="{{M}echanisms of {A}utoantibody-{I}nduced {P}athology}",
   Journal="Front Immunol",
   Year="2017",
   Volume="8",
   Pages="603"
}

Dammermann, W., Polywka, S., Dettmann, I., Mindorf, S., Komorowski, L., Wehmeyer, M., Schulze Zur Wiesch, J., Stocker, W. and Luth, S.: Autoantibodies against rods and rings-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a real life cohort Med. Microbiol. Immunol., vol. 206, no. 5, pp. 379-382, t 27957508, 2017

% 28815296 
@Article{pmid28815296,
   Author="Dammermann, W.  and Polywka, S.  and Dettmann, I.  and Mindorf, S.  and Komorowski, L.  and Wehmeyer, M.  and Schulze Zur Wiesch, J.  and Stocker, W.  and Luth, S. ",
   Title="{{A}utoantibodies against "rods and rings"-related {I}{M}{P}{D}{H}2 in hepatitis {C} genotype 1 and {D}{A}{A} therapy in a "real life" cohort}",
   Journal="Med. Microbiol. Immunol.",
   Year="2017",
   Volume="206",
   Number="5",
   Pages="379--382",
   Month="Oct"
}

% 27957508 
@Article{pmid27957508,
   Author="Miske, R.  and Gross, C. C.  and Scharf, M.  and Golombeck, K. S.  and Hartwig, M.  and Bhatia, U.  and Schulte-Mecklenbeck, A.  and Bonte, K.  and Strippel, C.  and Schols, L.  and Synofzik, M.  and Lohmann, H.  and Dettmann, I. M.  and Deppe, M.  and Mindorf, S.  and Warnecke, T.  and Denno, Y.  and Teegen, B.  and Probst, C.  and Brakopp, S.  and Wandinger, K. P.  and Wiendl, H.  and Stocker, W.  and Meuth, S. G.  and Komorowski, L.  and Melzer, N. ",
   Title="{{N}eurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration}",
   Journal="Neurol Neuroimmunol Neuroinflamm",
   Year="2017",
   Volume="4",
   Number="1",
   Pages="e307",
   Month="Jan"
}

% 27490202 
@Article{pmid27490202,
   Author="Fraune, J.  and Gerlach, S.  and Rentzsch, K.  and Teegen, B.  and Lederer, S.  and Affeldt, K.  and Fechner, K.  and Danckwardt, M.  and Voigt, J.  and Probst, C.  and Komorowski, L.  and Stocker, W. ",
   Title="{{M}ultiparametric serological testing in autoimmune encephalitis using computer-aided immunofluorescence microscopy ({C}{A}{I}{F}{M})}",
   Journal="Autoimmun Rev",
   Year="2016",
   Volume="15",
   Number="10",
   Pages="937--942",
   Month="Oct"
}

% 25809299 
@Article{pmid25809299,
   Author="Scharf, M.  and Miske, R.  and Heidenreich, F.  and Giess, R.  and Landwehr, P.  and Blocker, I. M.  and Begemann, N.  and Denno, Y.  and Tiede, S.  and Dahnrich, C.  and Schlumberger, W.  and Unger, M.  and Teegen, B.  and Stocker, W.  and Probst, C.  and Komorowski, L. ",
   Title="{{N}euronal {N}a+/{K}+ {A}{T}{P}ase is an autoantibody target in paraneoplastic neurologic syndrome}",
   Journal="Neurology",
   Year="2015",
   Volume="84",
   Number="16",
   Pages="1673--1679",
   Month="Apr"
}

% 25745634 
@Article{pmid25745634,
   Author="Probst, C.  and Komorowski, L.  and de Graaff, E.  and van Coevorden-Hameete, M.  and Rogemond, V.  and Honnorat, J.  and Sabeter, L.  and Graus, F.  and Jarius, S.  and Voltz, R.  and Wildemann, B.  and Franciotta, D.  and Blocker, I. M.  and Schlumberger, W.  and Stocker, W.  and Sillevis Smitt, P. A. ",
   Title="{{S}tandardized test for anti-{T}r/{D}{N}{E}{R} in patients with paraneoplastic cerebellar degeneration}",
   Journal="Neurol Neuroimmunol Neuroinflamm",
   Year="2015",
   Volume="2",
   Number="2",
   Pages="e68",
   Month="Apr"
}

% 25498830 
@Article{pmid25498830,
   Author="Jarius, S.  and Scharf, M.  and Begemann, N.  and Stocker, W.  and Probst, C.  and Serysheva, I. I.  and Nagel, S.  and Graus, F.  and Psimaras, D.  and Wildemann, B.  and Komorowski, L. ",
   Title="{{A}ntibodies to the inositol 1,4,5-trisphosphate receptor type 1 ({I}{T}{P}{R}1) in cerebellar ataxia}",
   Journal="J Neuroinflammation",
   Year="2014",
   Volume="11",
   Pages="206",
   Month="Dec"
}

% 25450001 
@Article{pmid25450001,
   Author="Dammermann, W.  and Bochmann, D.  and Bentzien, F.  and Komorowski, L.  and Steinhagen, K.  and Ullrich, S.  and van Lunzen, J.  and Luth, S. ",
   Title="{{C}{M}{V} specific cytokine release assay in whole blood is optimized by combining synthetic {C}{M}{V} peptides and toll like receptor agonists}",
   Journal="J. Immunol. Methods",
   Year="2014",
   Volume="414",
   Pages="82--90",
   Month="Dec"
}

% 25320100 
@Article{pmid25320100,
   Author="Tobin, W. O.  and Lennon, V. A.  and Komorowski, L.  and Probst, C.  and Clardy, S. L.  and Aksamit, A. J.  and Appendino, J. P.  and Lucchinetti, C. F.  and Matsumoto, J. Y.  and Pittock, S. J.  and Sandroni, P.  and Tippmann-Peikert, M.  and Wirrell, E. C.  and McKeon, A. ",
   Title="{{D}{P}{P}{X} potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients}",
   Journal="Neurology",
   Year="2014",
   Volume="83",
   Number="20",
   Pages="1797--1803",
   Month="Nov"
}

% 24075959 
@Article{pmid24075959,
   Author="Schlumberger, W.  and Hornig, N.  and Lange, S.  and Probst, C.  and Komorowski, L.  and Fechner, K.  and Dahnrich, C.  and Stocker, W. ",
   Title="{{D}ifferential diagnosis of membranous nephropathy with autoantibodies to phospholipase {A}2 receptor 1}",
   Journal="Autoimmun Rev",
   Year="2014",
   Volume="13",
   Number="2",
   Pages="108--113",
   Month="Feb"
}

% 23568169 
@Article{pmid23568169,
   Author="Stocker, W.  and Saschenbrecker, S.  and Rentzsch, K.  and Komorowski, L.  and Probst, C. ",
   Title="{[{A}utoantibody diagnostics in neurology using native and recombinant antigenic substrates]}",
   Journal="Nervenarzt",
   Year="2013",
   Volume="84",
   Number="4",
   Pages="471--476",
   Month="Apr"
}

Jendrek, S. T., Gotthardt, D., Nitzsche, T., Widmann, L., Korf, T., Michaels, M. A., Weiss, K. H., Liaskou, E., Vesterhus, M., Karlsen, T. H., Mindorf, S., Schemmer, P., Bar, F., Teegen, B., Schroder, T., Ehlers, M., Hammers, C. M., Komorowski, L., Lehnert, H., Fellermann, K., Derer, S., Hov, J. R. and Sina, C.: Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis Gut, vol. 66, no. 1, pp. 137-144, 2017

% 27406039 
@Article{pmid27406039,
   Author="Jendrek, S. T.  and Gotthardt, D.  and Nitzsche, T.  and Widmann, L.  and Korf, T.  and Michaels, M. A.  and Weiss, K. H.  and Liaskou, E.  and Vesterhus, M.  and Karlsen, T. H.  and Mindorf, S.  and Schemmer, P.  and Bar, F.  and Teegen, B.  and Schroder, T.  and Ehlers, M.  and Hammers, C. M.  and Komorowski, L.  and Lehnert, H.  and Fellermann, K.  and Derer, S.  and Hov, J. R.  and Sina, C. ",
   Title="{{A}nti-{G}{P}2 {I}g{A} autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis}",
   Journal="Gut",
   Year="2017",
   Volume="66",
   Number="1",
   Pages="137--144",
   Month="01"
}

2016

Mersmann, M., Dworschak, J., Ebermann, K., Komorowski, L., Schlumberger, W., Stocker, W., Zillikens, D., Probst, C. and Schmidt, E.: Immunoadsorber for specific apheresis of autoantibodies in the treatment of bullous pemphigoid Arch. Dermatol. Res., vol. 308, no. 1, pp. 31-38, n, 2016

@Article{pmid26498290,
   Author="Mersmann, M.  and Dworschak, J.  and Ebermann, K.  and Komorowski, L.  and Schlumberger, W.  and Stocker, W.  and Zillikens, D.  and Probst, C.  and Schmidt, E. ",
   Title="{{I}mmunoadsorber for specific apheresis of autoantibodies in the treatment of bullous pemphigoid}",
   Journal="Arch. Dermatol. Res.",
   Year="2016",
   Volume="308",
   Number="1",
   Pages="31--38",
   Month="Jan"
}

2014

Langenhan, J., Dworschak, J., Saschenbrecker, S., Komorowski, L., Schlumberger, W., Stocker, W., Westermann, J., Recke, A., Zillikens, D., Schmidt, E. and Probst, C.: Specific immunoadsorption of pathogenic autoantibodies in pemphigus requires the entire ectodomains of desmogleins Exp. Dermatol., vol. 23, no. 4, pp. 253-259, r, 2014

@Article{pmid24533885,
   Author="Langenhan, J.  and Dworschak, J.  and Saschenbrecker, S.  and Komorowski, L.  and Schlumberger, W.  and Stocker, W.  and Westermann, J.  and Recke, A.  and Zillikens, D.  and Schmidt, E.  and Probst, C. ",
   Title="{{S}pecific immunoadsorption of pathogenic autoantibodies in pemphigus requires the entire ectodomains of desmogleins}",
   Journal="Exp. Dermatol.",
   Year="2014",
   Volume="23",
   Number="4",
   Pages="253--259",
   Month="Apr"

2012

Komorowski, L., Muller, R., Vorobyev, A., Probst, C., Recke, A., Jonkman, M. F., Hashimoto, T., Kim, S. C., Groves, R., Ludwig, R. J., Zillikens, D., Stocker, W. and Schmidt, E.: Sensitive and specific assays for routine serological diagnosis of epidermolysis bullosa acquisita J Am Acad Dermatol, b, 2012

@Article{pmid22341608,
   Author="Komorowski, L.  and Muller, R.  and Vorobyev, A.  and Probst, C.  and Recke, A.  and Jonkman, M. F.  and Hashimoto, T.  and Kim, S. C.  and Groves, R.  and Ludwig, R. J.  and Zillikens, D.  and Stocker, W.  and Schmidt, E. ",
   Title="{{S}ensitive and specific assays for routine serological diagnosis of epidermolysis bullosa acquisita}",
   Journal="J Am Acad Dermatol",
   Year="2012",
   Month="Feb"
}

Blocker, I. M., Dahnrich, C., Probst, C., Komorowski, L., Saschenbrecker, S., Schlumberger, W., Stocker, W., Zillikens, D. and Schmidt, E.: Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid Br J Dermatol, n, 2012

@Article{pmid22242606,
   Author="Blocker, I. M.  and Dahnrich, C.  and Probst, C.  and Komorowski, L.  and Saschenbrecker, S.  and Schlumberger, W.  and Stocker, W.  and Zillikens, D.  and Schmidt, E. ",
   Title="{{E}pitope mapping of {B}{P}230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid}",
   Journal="Br J Dermatol",
   Year="2012",
   Month="Jan"
}

2011

Kasperkiewicz, M., Dahnrich, C., Probst, C., Komorowski, L., Stocker, W., Schlumberger, W., Zillikens, D. and Rose, C.: Novel assay for detecting celiac disease-associated autoantibodies in dermatitis herpetiformis using deamidated gliadin-analogous fusion peptides J. Am. Acad. Dermatol., g, 2011

@Article{pmid21840083,
   Author="Kasperkiewicz, M.  and Dahnrich, C.  and Probst, C.  and Komorowski, L.  and Stocker, W.  and Schlumberger, W.  and Zillikens, D.  and Rose, C. ",
   Title="{{N}ovel assay for detecting celiac disease-associated autoantibodies in dermatitis herpetiformis using deamidated gliadin-analogous fusion peptides}",
   Journal="J. Am. Acad. Dermatol.",
   Year="2011",
   Month="Aug"
}