Univ.-Prof. Dr. med. Christian Sina


Institute of Nutritional Medicine
University of Lübeck
Ratzeburger Allee 160
23562 Lübeck

Email:
Phone:
+49 451-3101-8400
Fax:
+49 451-3101-8404

Publications

2019

  • Vorobyev, A., Gupta, Y., Sezin, T., Koga, H., Bartsch, Y. C., Belheouane, M., Kunzel, S., Sina, C., Schilf, P., Korber-Ahrens, H., Beltsiou, F., Lara Ernst, A., Khil`chenko, S., Al-Aasam, H., Manz, R. A., Diehl, S., Steinhaus, M., Jascholt, J., Kouki, P., Boehncke, W. H., Mayadas, T. N., Zillikens, D., Sadik, C. D., Nishi, H., Ehlers, M., Moller, S., Bieber, K., Baines, J. F., Ibrahim, S. M. and Ludwig, R. J.: Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line Nat Commun, vol. 10, no. 1, pp. 4097, p, 2019
    BibTeX Pubmed Auszeichnung
    % 31506438 
    @Article{pmid31506438,
       Author="Vorobyev, A.  and Gupta, Y.  and Sezin, T.  and Koga, H.  and Bartsch, Y. C.  and Belheouane, M.  and Kunzel, S.  and Sina, C.  and Schilf, P.  and Korber-Ahrens, H.  and Beltsiou, F.  and Lara Ernst, A.  and Khil'chenko, S.  and Al-Aasam, H.  and Manz, R. A.  and Diehl, S.  and Steinhaus, M.  and Jascholt, J.  and Kouki, P.  and Boehncke, W. H.  and Mayadas, T. N.  and Zillikens, D.  and Sadik, C. D.  and Nishi, H.  and Ehlers, M.  and Moller, S.  and Bieber, K.  and Baines, J. F.  and Ibrahim, S. M.  and Ludwig, R. J. ",
       Title="{{G}ene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line}",
       Journal="Nat Commun",
       Year="2019",
       Volume="10",
       Number="1",
       Pages="4097",
       Month="Sep"
    }
    

2018

  • Sina, C., Kemper, C. and Derer, S.: The intestinal complement system in inflammatory bowel disease: Shaping intestinal barrier function Semin. Immunol., vol. 37, pp. 66-73, 2018
    BibTeX Pubmed Auszeichnung
    % 29486961 
    @Article{pmid29486961,
       Author="Sina, C.  and Kemper, C.  and Derer, S. ",
       Title="{{T}he intestinal complement system in inflammatory bowel disease: {S}haping intestinal barrier function}",
       Journal="Semin. Immunol.",
       Year="2018",
       Volume="37",
       Pages="66--73",
       Month="06"
    }
    
  • Staats, S., Rimbach, G., Kuenstner, A., Graspeuntner, S., Rupp, J., Busch, H., Sina, C., Ipharraguerre, I. R. and Wagner, A. E.: Lithocholic Acid Improves the Survival of Drosophila Melanogaster Mol Nutr Food Res, vol. 62, no. 20, pp. e1800424, 2018
    BibTeX Pubmed Auszeichnung
    % 30051966 
    @Article{pmid30051966,
       Author="Staats, S.  and Rimbach, G.  and Kuenstner, A.  and Graspeuntner, S.  and Rupp, J.  and Busch, H.  and Sina, C.  and Ipharraguerre, I. R.  and Wagner, A. E. ",
       Title="{{L}ithocholic {A}cid {I}mproves the {S}urvival of {D}rosophila {M}elanogaster}",
       Journal="Mol Nutr Food Res",
       Year="2018",
       Volume="62",
       Number="20",
       Pages="e1800424",
       Month="10"
    }
  • Damgaard, M. T. F., P?rregaard, S. I., S?gaard, I., Agerholm, M., Paulson, J. N., Treebak, J. T., Sina, C., Holm, J. B., Kristiansen, K. and Jensen, B. A. H.: Age-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat J. Nutr. Biochem., vol. 54, pp. 66-76, r, 2018
    BibTeX Pubmed Auszeichnung
    % 29268121 
    @Article{pmid29268121,
       Author="Damgaard, M. T. F.  and P?rregaard, S. I.  and S?gaard, I.  and Agerholm, M.  and Paulson, J. N.  and Treebak, J. T.  and Sina, C.  and Holm, J. B.  and Kristiansen, K.  and Jensen, B. A. H. ",
       Title="{{A}ge-dependent alterations of glucose clearance and homeostasis are temporally separated and modulated by dietary fat}",
       Journal="J. Nutr. Biochem.",
       Year="2018",
       Volume="54",
       Pages="66--76",
       Month="Apr"
    }
    
  • Schroder, T., Kistenmacher, A., Smollich, M. and Sina, C.: [Causes, Diagnostic and Therapeutical Procedures of Malassimilation] Dtsch. Med. Wochenschr., vol. 143, no. 10, pp. 704-712, y, 2018
    BibTeX Pubmed Auszeichnung
    % 29727885 
    @Article{pmid29727885,
       Author="Schroder, T.  and Kistenmacher, A.  and Smollich, M.  and Sina, C. ",
       Title="{[{C}auses, {D}iagnostic and {T}herapeutical {P}rocedures of {M}alassimilation]}",
       Journal="Dtsch. Med. Wochenschr.",
       Year="2018",
       Volume="143",
       Number="10",
       Pages="704--712",
       Month="May"
    }

2017

  • Hirose, M., Schilf, P., Rohde, S., Gupta, Y., Sancerni, T., Alves-Guerra, M. C., Sina, C., Jaster, R., Miroux, B. and Ibrahim, S. M.: The mitochondrial uncoupling protein 2 gene is causal for the spontaneous polycystic liver diseases in mice Mitochondrion, v, 2017
    BibTeX Pubmed Auszeichnung
    % 29154852 
    @Article{pmid29154852,
       Author="Hirose, M.  and Schilf, P.  and Rohde, S.  and Gupta, Y.  and Sancerni, T.  and Alves-Guerra, M. C.  and Sina, C.  and Jaster, R.  and Miroux, B.  and Ibrahim, S. M. ",
       Title="{{T}he mitochondrial uncoupling protein 2 gene is causal for the spontaneous polycystic liver diseases in mice}",
       Journal="Mitochondrion",
       Year="2017",
       Month="Nov"
    }
    
    
  • Sunderhauf, A., Skibbe, K., Preisker, S., Ebbert, K., Verschoor, A., Karsten, C. M., Kemper, C., Huber-Lang, M., Basic, M., Bleich, A., Buning, J., Fellermann, K., Sina, C. and Derer, S.: Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease? Mol. Immunol., vol. 90, pp. 227-238, t, 2017
    BibTeX Pubmed Auszeichnung
    @Article{pmid28843904,
       Author="Sunderhauf, A.  and Skibbe, K.  and Preisker, S.  and Ebbert, K.  and Verschoor, A.  and Karsten, C. M.  and Kemper, C.  and Huber-Lang, M.  and Basic, M.  and Bleich, A.  and Buning, J.  and Fellermann, K.  and Sina, C.  and Derer, S. ",
       Title="{{R}egulation of epithelial cell expressed {C}3 in the intestine - {R}elevance for the pathophysiology of inflammatory bowel disease?}",
       Journal="Mol. Immunol.",
       Year="2017",
       Volume="90",
       Pages="227--238",
       Month="Oct"
    }
    
  • Heppe, E. N., Tofern, S., Schulze, F. S., Ishiko, A., Shimizu, A., Sina, C., Zillikens, D., Kohl, J., Goletz, S. and Schmidt, E.: Experimental Laminin 332 Mucous Membrane Pemphigoid Critically Involves C5aR1 and Reflects Clinical and Immunopathological Characteristics of the Human Disease J. Invest. Dermatol., vol. 137, no. 8, pp. 1709-1718, g, 2017
    BibTeX Pubmed Auszeichnung
    @Article{pmid28456612,
       Author="Heppe, E. N.  and Tofern, S.  and Schulze, F. S.  and Ishiko, A.  and Shimizu, A.  and Sina, C.  and Zillikens, D.  and Kohl, J.  and Goletz, S.  and Schmidt, E. ",
       Title="{{E}xperimental {L}aminin 332 {M}ucous {M}embrane {P}emphigoid {C}ritically {I}nvolves {C}5a{R}1 and {R}eflects {C}linical and {I}mmunopathological {C}haracteristics of the {H}uman {D}isease}",
       Journal="J. Invest. Dermatol.",
       Year="2017",
       Volume="137",
       Number="8",
       Pages="1709--1718",
       Month="Aug"
    }
    
  • Pagel, R., Bar, F., Schroder, T., Sunderhauf, A., Kunstner, A., Ibrahim, S. M., Autenrieth, S. E., Kalies, K., Konig, P., Tsang, A. H., Bettenworth, D., Divanovic, S., Lehnert, H., Fellermann, K., Oster, H., Derer, S. and Sina, C.: Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine FASEB J., vol. 31, no. 11, pp. 4707-4719, 2017
    BibTeX Pubmed Auszeichnung
    % 28710114 
    @Article{pmid28710114,
       Author="Pagel, R.  and Bar, F.  and Schroder, T.  and Sunderhauf, A.  and Kunstner, A.  and Ibrahim, S. M.  and Autenrieth, S. E.  and Kalies, K.  and Konig, P.  and Tsang, A. H.  and Bettenworth, D.  and Divanovic, S.  and Lehnert, H.  and Fellermann, K.  and Oster, H.  and Derer, S.  and Sina, C. ",
       Title="{{C}ircadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine}",
       Journal="FASEB J.",
       Year="2017",
       Volume="31",
       Number="11",
       Pages="4707--4719",
       Month="11"
    }
    
  • Jendrek, S. T., Gotthardt, D., Nitzsche, T., Widmann, L., Korf, T., Michaels, M. A., Weiss, K. H., Liaskou, E., Vesterhus, M., Karlsen, T. H., Mindorf, S., Schemmer, P., Bar, F., Teegen, B., Schroder, T., Ehlers, M., Hammers, C. M., Komorowski, L., Lehnert, H., Fellermann, K., Derer, S., Hov, J. R. and Sina, C.: Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis Gut, vol. 66, no. 1, pp. 137-144, 2017
    BibTeX Pubmed Auszeichnung
    % 27406039 
    @Article{pmid27406039,
       Author="Jendrek, S. T.  and Gotthardt, D.  and Nitzsche, T.  and Widmann, L.  and Korf, T.  and Michaels, M. A.  and Weiss, K. H.  and Liaskou, E.  and Vesterhus, M.  and Karlsen, T. H.  and Mindorf, S.  and Schemmer, P.  and Bar, F.  and Teegen, B.  and Schroder, T.  and Ehlers, M.  and Hammers, C. M.  and Komorowski, L.  and Lehnert, H.  and Fellermann, K.  and Derer, S.  and Hov, J. R.  and Sina, C. ",
       Title="{{A}nti-{G}{P}2 {I}g{A} autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis}",
       Journal="Gut",
       Year="2017",
       Volume="66",
       Number="1",
       Pages="137--144",
       Month="01"
    }

2016

  • Hirose, M., Schilf, P., Lange, F., Mayer, J., Reichart, G., Maity, P., Johren, O., Schwaninger, M., Scharffetter-Kochanek, K., Sina, C., Sadik, C. D., Kohling, R., Miroux, B. and Ibrahim, S. M.: Uncoupling protein 2 protects mice from aging Mitochondrion, vol. 30, pp. 42-50, p, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid27364833,
       Author="Hirose, M.  and Schilf, P.  and Lange, F.  and Mayer, J.  and Reichart, G.  and Maity, P.  and Johren, O.  and Schwaninger, M.  and Scharffetter-Kochanek, K.  and Sina, C.  and Sadik, C. D.  and Kohling, R.  and Miroux, B.  and Ibrahim, S. M. ",
       Title="{{U}ncoupling protein 2 protects mice from aging}",
       Journal="Mitochondrion",
       Year="2016",
       Volume="30",
       Pages="42--50",
       Month="Sep"
    }
  • Schroder, T., Kucharczyk, D., Bar, F., Pagel, R., Derer, S., Jendrek, S. T., Sunderhauf, A., Brethack, A. K., Hirose, M., Moller, S., Kunstner, A., Bischof, J., Weyers, I., Heeren, J., Koczan, D., Schmid, S. M., Divanovic, S., Giles, D. A., Adamski, J., Fellermann, K., Lehnert, H., Kohl, J., Ibrahim, S. and Sina, C.: Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis Mol Metab, vol. 5, no. 4, pp. 283-295, r, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid27069868,
       Author="Schroder, T.  and Kucharczyk, D.  and Bar, F.  and Pagel, R.  and Derer, S.  and Jendrek, S. T.  and Sunderhauf, A.  and Brethack, A. K.  and Hirose, M.  and Moller, S.  and Kunstner, A.  and Bischof, J.  and Weyers, I.  and Heeren, J.  and Koczan, D.  and Schmid, S. M.  and Divanovic, S.  and Giles, D. A.  and Adamski, J.  and Fellermann, K.  and Lehnert, H.  and Kohl, J.  and Ibrahim, S.  and Sina, C. ",
       Title="{{M}itochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis}",
       Journal="Mol Metab",
       Year="2016",
       Volume="5",
       Number="4",
       Pages="283--295",
       Month="Apr"
    }
  • Dankowski, T., Schroder, T., Moller, S., Yu, X., Ellinghaus, D., Bar, F., Fellermann, K., Lehnert, H., Schreiber, S., Franke, A., Sina, C., Ibrahim, S. M. and Konig, I. R.: Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study BMC Gastroenterol, vol. 16, no. 1, pp. 118, t, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid27716073,
       Author="Dankowski, T.  and Schroder, T.  and Moller, S.  and Yu, X.  and Ellinghaus, D.  and Bar, F.  and Fellermann, K.  and Lehnert, H.  and Schreiber, S.  and Franke, A.  and Sina, C.  and Ibrahim, S. M.  and Konig, I. R. ",
       Title="{{M}ale-specific association between {M}{T}-{N}{D}4 11719 {A}/{G} polymorphism and ulcerative colitis: a mitochondria-wide genetic association study}",
       Journal="BMC Gastroenterol",
       Year="2016",
       Volume="16",
       Number="1",
       Pages="118",
       Month="Oct"
    }
  • Hirose, M., Schilf, P., Gupta, Y., Wright, M. N., Wright, M. N., Johren, O., Wagner, A. E., Sina, C., Ziegler, A., Ristow, M. and Ibrahim, S. M.: Lifespan effects of mitochondrial mutations Nature, vol. 540, no. 7633, pp. E13-E14, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid27974775,
       Author="Hirose, M.  and Schilf, P.  and Gupta, Y.  and Wright, M. N.  and Wright, M. N.  and Johren, O.  and Wagner, A. E.  and Sina, C.  and Ziegler, A.  and Ristow, M.  and Ibrahim, S. M. ",
       Title="{{L}ifespan effects of mitochondrial mutations}",
       Journal="Nature",
       Year="2016",
       Volume="540",
       Number="7633",
       Pages="E13-E14",
       Month="12"
    }
    

2014

  • Bar, F., Foh, B., Pagel, R., Schroder, T., Schlichting, H., Hirose, M., Lemcke, S., Klinger, A., Konig, P., Karsten, C. M., Buning, J., Lehnert, H., Fellermann, K., Ibrahim, S. M. and Sina, C.: Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice PLoS ONE, vol. 9, no. 7, pp. 02347, 2014
    BibTeX Pubmed Auszeichnung
    @Article{pmid25051500,
       Author="Bar, F.  and Foh, B.  and Pagel, R.  and Schroder, T.  and Schlichting, H.  and Hirose, M.  and Lemcke, S.  and Klinger, A.  and Konig, P.  and Karsten, C. M.  and Buning, J.  and Lehnert, H.  and Fellermann, K.  and Ibrahim, S. M.  and Sina, C. ",
       Title="{{C}arboxypeptidase {E} modulates intestinal immune homeostasis and protects against experimental colitis in mice}",
       Journal="PLoS ONE",
       Year="2014",
       Volume="9",
       Number="7",
       Pages="e102347"