Dr. rer. nat. Christian Karsten


Institute for Systemic Inflammation Research (ISEF)
University of Lübeck
Ratzeburger Allee 160
23562 Lübeck

Email:
Phone:
+49 451 500 51423
Fax:
+49 451 500 3069

Publications

2019

  • Kovacs, B., Tillmann, J., Freund, L. C., Nimmerjahn, F., Sadik, C. D., Bieber, K., Ludwig, R. J., Karsten, C. M. and K?hl, J.: Fcγ Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita Front Immunol, vol. 10, pp. 12, 2019
    BibTeX Pubmed Auszeichnung
    % 31993051 
    @Article{pmid31993051,
       Author="Kovacs, B.  and Tillmann, J.  and Freund, L. C.  and Nimmerjahn, F.  and Sadik, C. D.  and Bieber, K.  and Ludwig, R. J.  and Karsten, C. M.  and K?hl, J. ",
       Title="{{F}cγ {R}eceptor {I}{I}{B} {C}ontrols {S}kin {I}nflammation in an {A}ctive {M}odel of {E}pidermolysis {B}ullosa {A}cquisita}",
       Journal="Front Immunol",
       Year="2019",
       Volume="10",
       Pages="3012"
    }
    

2018

  • Karsten, C. M., Beckmann, T., Holtsche, M. M., Tillmann, J., Tofern, S., Schulze, F. S., Heppe, E. N., Ludwig, R. J., Zillikens, D., Konig, I. R., Kohl, J. and Schmidt, E.: Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2 Front Immunol, vol. 9, pp. 8, 2018
    BibTeX Pubmed Auszeichnung
    @Article{pmid29599777,
       Author="Karsten, C. M.  and Beckmann, T.  and Holtsche, M. M.  and Tillmann, J.  and Tofern, S.  and Schulze, F. S.  and Heppe, E. N.  and Ludwig, R. J.  and Zillikens, D.  and Konig, I. R.  and Kohl, J.  and Schmidt, E. ",
       Title="{{T}issue {D}estruction in {B}ullous {P}emphigoid {C}an {B}e {C}omplement {I}ndependent and {M}ay {B}e {M}itigated by {C}5a{R}2}",
       Journal="Front Immunol",
       Year="2018",
       Volume="9",
       Pages="488"
    }
    
    
  • Lamprecht, P., Kerstein, A., Klapa, S., Schinke, S., Karsten, C. M., Yu, X., Ehlers, M., Epplen, J. T., Holl-Ulrich, K., Wiech, T., Kalies, K., Lange, T., Laudien, M., Laskay, T., Gemoll, T., Schumacher, U., Ullrich, S., Busch, H., Ibrahim, S., Fischer, N., Hasselbacher, K., Pries, R., Petersen, F., Weppner, G., Manz, R., Humrich, J. Y., Nieberding, R., Riemekasten, G. and Muller, A.: Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides Front Immunol, vol. 9, 2018
    BibTeX Pubmed Auszeichnung
    % 29686675 
    @Article{pmid29686675,
       Author="Lamprecht, P.  and Kerstein, A.  and Klapa, S.  and Schinke, S.  and Karsten, C. M.  and Yu, X.  and Ehlers, M.  and Epplen, J. T.  and Holl-Ulrich, K.  and Wiech, T.  and Kalies, K.  and Lange, T.  and Laudien, M.  and Laskay, T.  and Gemoll, T.  and Schumacher, U.  and Ullrich, S.  and Busch, H.  and Ibrahim, S.  and Fischer, N.  and Hasselbacher, K.  and Pries, R.  and Petersen, F.  and Weppner, G.  and Manz, R.  and Humrich, J. Y.  and Nieberding, R.  and Riemekasten, G.  and Muller, A. ",
       Title="{{P}athogenetic and {C}linical {A}spects of {A}nti-{N}eutrophil {C}ytoplasmic {A}utoantibody-{A}ssociated {V}asculitides}",
       Journal="Front Immunol",
       Year="2018",
       Volume="9",
       Pages="680"
    }
  • Broker, K., Figge, J., Magnusen, A. F., Manz, R. A., Kohl, J. and Karsten, C. M.: A Novel Role for C5a in B-1 Cell Homeostasis Front Immunol, vol. 9, pp. 8, 2018
    BibTeX Pubmed Auszeichnung
    @Article{pmid29520270,
       Author="Broker, K.  and Figge, J.  and Magnusen, A. F.  and Manz, R. A.  and Kohl, J.  and Karsten, C. M. ",
       Title="{{A} {N}ovel {R}ole for {C}5a in {B}-1 {C}ell {H}omeostasis}",
       Journal="Front Immunol",
       Year="2018",
       Volume="9",
       Pages="258"
    }
    

2017

  • Hartz, A., Pagel, J., Humberg, A., Preuss, M., Schreiter, L., Rupp, J., Figge, J., Karsten, C. M., Nurnberg, P., Herting, E., Gopel, W. and Hartel, C.: The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants PLoS ONE, vol. 12, no. 5, pp. 178032, 2017
    BibTeX Pubmed Auszeichnung
    @Article{pmid28558032,
       Author="Hartz, A.  and Pagel, J.  and Humberg, A.  and Preuss, M.  and Schreiter, L.  and Rupp, J.  and Figge, J.  and Karsten, C. M.  and Nurnberg, P.  and Herting, E.  and Gopel, W.  and Hartel, C. ",
       Title="{{T}he association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants}",
       Journal="PLoS ONE",
       Year="2017",
       Volume="12",
       Number="5",
       Pages="e0178032"
    }
    
  • Sunderhauf, A., Skibbe, K., Preisker, S., Ebbert, K., Verschoor, A., Karsten, C. M., Kemper, C., Huber-Lang, M., Basic, M., Bleich, A., Buning, J., Fellermann, K., Sina, C. and Derer, S.: Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease? Mol. Immunol., vol. 90, pp. 227-238, t, 2017
    BibTeX Pubmed Auszeichnung
    @Article{pmid28843904,
       Author="Sunderhauf, A.  and Skibbe, K.  and Preisker, S.  and Ebbert, K.  and Verschoor, A.  and Karsten, C. M.  and Kemper, C.  and Huber-Lang, M.  and Basic, M.  and Bleich, A.  and Buning, J.  and Fellermann, K.  and Sina, C.  and Derer, S. ",
       Title="{{R}egulation of epithelial cell expressed {C}3 in the intestine - {R}elevance for the pathophysiology of inflammatory bowel disease?}",
       Journal="Mol. Immunol.",
       Year="2017",
       Volume="90",
       Pages="227--238",
       Month="Oct"
    }
    
  • Laumonnier, Y., Karsten, C. M. and Kohl, J.: Novel insights into the expression pattern of anaphylatoxin receptors in mice and men Mol. Immunol., n, 2017
    BibTeX Pubmed Auszeichnung
    @Article{pmid28600003,
       Author="Laumonnier, Y.  and Karsten, C. M.  and Kohl, J. ",
       Title="{{N}ovel insights into the expression pattern of anaphylatoxin receptors in mice and men}",
       Journal="Mol. Immunol.",
       Year="2017",
       Month="Jun"
    }
    
  • Karsten, C. M., Wiese, A. V., Mey, F., Figge, J., Woodruff, T. M., Reuter, T., Scurtu, O., Kordowski, A., Almeida, L. N., Briukhovetska, D., Quell, K. M., Sun, J., Ender, F., Schmudde, I., Vollbrandt, T., Laumonnier, Y. and Kohl, J.: Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse J. Immunol., vol. 199, no. 9, pp. 3234-3248, v, 2017
    BibTeX Pubmed Auszeichnung
    @Article{pmid28864475,
       Author="Karsten, C. M.  and Wiese, A. V.  and Mey, F.  and Figge, J.  and Woodruff, T. M.  and Reuter, T.  and Scurtu, O.  and Kordowski, A.  and Almeida, L. N.  and Briukhovetska, D.  and Quell, K. M.  and Sun, J.  and Ender, F.  and Schmudde, I.  and Vollbrandt, T.  and Laumonnier, Y.  and Kohl, J. ",
       Title="{{M}onitoring {C}5a{R}2 {E}xpression {U}sing a {F}loxed td{T}omato-{C}5a{R}2 {K}nock-{I}n {M}ouse}",
       Journal="J. Immunol.",
       Year="2017",
       Volume="199",
       Number="9",
       Pages="3234--3248",
       Month="Nov"
    }
  • Quell, K. M., Karsten, C. M., Kordowski, A., Almeida, L. N., Briukhovetska, D., Wiese, A. V., Sun, J., Ender, F., Antoniou, K., Schroder, T., Schmudde, I., Berger, J. L., Konig, P., Vollbrandt, T., Laumonnier, Y. and Kohl, J.: Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse J. Immunol., vol. 199, no. 2, pp. 688-706, l, 2017
    BibTeX Pubmed Auszeichnung
    @Article{pmid28626064,
       Author="Quell, K. M.  and Karsten, C. M.  and Kordowski, A.  and Almeida, L. N.  and Briukhovetska, D.  and Wiese, A. V.  and Sun, J.  and Ender, F.  and Antoniou, K.  and Schroder, T.  and Schmudde, I.  and Berger, J. L.  and Konig, P.  and Vollbrandt, T.  and Laumonnier, Y.  and Kohl, J. ",
       Title="{{M}onitoring {C}3a{R} {E}xpression {U}sing a {F}loxed td{T}omato-{C}3a{R} {R}eporter {K}nock-in {M}ouse}",
       Journal="J. Immunol.",
       Year="2017",
       Volume="199",
       Number="2",
       Pages="688--706",
       Month="Jul"
    }
  • Gemoll, T., Kollbeck, S. L., Karstens, K. F., Ho, G. G., Hartwig, S., Strohkamp, S., Schillo, K., Thorns, C., Oberlander, M., Kalies, K., Lehr, S. and Habermann, J. K.: EB1 protein alteration characterizes sporadic but not ulcerative colitis associated colorectal cancer Oncotarget, vol. 8, no. 33, pp. 54939-54950, g, 2017
    BibTeX Pubmed Auszeichnung
    @Article{pmid28903393,
       Author="Gemoll, T.  and Kollbeck, S. L.  and Karstens, K. F.  and Ho, G. G.  and Hartwig, S.  and Strohkamp, S.  and Schillo, K.  and Thorns, C.  and Oberlander, M.  and Kalies, K.  and Lehr, S.  and Habermann, J. K. ",
       Title="{{E}{B}1 protein alteration characterizes sporadic but not ulcerative colitis associated colorectal cancer}",
       Journal="Oncotarget",
       Year="2017",
       Volume="8",
       Number="33",
       Pages="54939--54950",
       Month="Aug"
    }

2016

  • Pagel, J., Hartz, A., Figge, J., Gille, C., Eschweiler, S., Petersen, K., Schreiter, L., Hammer, J., Karsten, C. M., Friedrich, D., Herting, E., Gopel, W., Rupp, J. and Hartel, C.: Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis Clin. Exp. Immunol., vol. 185, no. 2, pp. 219-227, g, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid27163159,
       Author="Pagel, J.  and Hartz, A.  and Figge, J.  and Gille, C.  and Eschweiler, S.  and Petersen, K.  and Schreiter, L.  and Hammer, J.  and Karsten, C. M.  and Friedrich, D.  and Herting, E.  and Gopel, W.  and Rupp, J.  and Hartel, C. ",
       Title="{{R}egulatory {T} cell frequencies are increased in preterm infants with clinical early-onset sepsis}",
       Journal="Clin. Exp. Immunol.",
       Year="2016",
       Volume="185",
       Number="2",
       Pages="219--227",
       Month="Aug"
    }
    
  • Verschoor, A., Karsten, C. M., Broadley, S. P., Laumonnier, Y. and Kohl, J.: Old dogs-new tricks: immunoregulatory properties of C3 and C5 cleavage fragments Immunol. Rev., vol. 274, no. 1, pp. 112-126, v, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid27782330,
       Author="Verschoor, A.  and Karsten, C. M.  and Broadley, S. P.  and Laumonnier, Y.  and Kohl, J. ",
       Title="{{O}ld dogs-new tricks: immunoregulatory properties of {C}3 and {C}5 cleavage fragments}",
       Journal="Immunol. Rev.",
       Year="2016",
       Volume="274",
       Number="1",
       Pages="112--126",
       Month="Nov"
    }
  • Kulkarni, U., Karsten, C. M., Kohler, T., Hammerschmidt, S., Bommert, K., Tiburzy, B., Meng, L., Thieme, L., Recke, A., Ludwig, R. J., Pollok, K., Kalies, K., Bogen, B., Boettcher, M., Kamradt, T., Hauser, A. E., Langer, C., Huber-Lang, M., Finkelman, F. D., Kohl, J., Wong, D. M. and Manz, R. A.: IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration J. Allergy Clin. Immunol., vol. 137, no. 5, pp. 1487-1497, y, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid26653800,
       Author="Kulkarni, U.  and Karsten, C. M.  and Kohler, T.  and Hammerschmidt, S.  and Bommert, K.  and Tiburzy, B.  and Meng, L.  and Thieme, L.  and Recke, A.  and Ludwig, R. J.  and Pollok, K.  and Kalies, K.  and Bogen, B.  and Boettcher, M.  and Kamradt, T.  and Hauser, A. E.  and Langer, C.  and Huber-Lang, M.  and Finkelman, F. D.  and Kohl, J.  and Wong, D. M.  and Manz, R. A. ",
       Title="{{I}{L}-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration}",
       Journal="J. Allergy Clin. Immunol.",
       Year="2016",
       Volume="137",
       Number="5",
       Pages="1487--1497",
       Month="May"
    }
    
  • Heyl, K. A., Karsten, C. M. and Slevogt, H.: Galectin-3 binds highly galactosylated IgG1 and is crucial for the IgG1 complex mediated inhibition of C5aReceptor induced immune responses Biochem. Biophys. Res. Commun., vol. 479, no. 1, pp. 86-90, t, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid27620493,
       Author="Heyl, K. A.  and Karsten, C. M.  and Slevogt, H. ",
       Title="{{G}alectin-3 binds highly galactosylated {I}g{G}1 and is crucial for the {I}g{G}1 complex mediated inhibition of {C}5a{R}eceptor induced immune responses}",
       Journal="Biochem. Biophys. Res. Commun.",
       Year="2016",
       Volume="479",
       Number="1",
       Pages="86--90",
       Month="Oct"
    }
    

2015

  • Karsten, C. M., Laumonnier, Y., Eurich, B., Ender, F., Broker, K., Roy, S., Czabanska, A., Vollbrandt, T., Figge, J. and Kohl, J.: Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse J. Immunol., vol. 194, no. 4, pp. 1841-1855, b, 2015
    BibTeX Pubmed Auszeichnung
    @Article{pmid25589074,
       Author="Karsten, C. M.  and Laumonnier, Y.  and Eurich, B.  and Ender, F.  and Broker, K.  and Roy, S.  and Czabanska, A.  and Vollbrandt, T.  and Figge, J.  and Kohl, J. ",
       Title="{{M}onitoring and {C}ell-{S}pecific {D}eletion of {C}5a{R}1 {U}sing a {N}ovel {F}loxed {G}{F}{P}-{C}5a{R}1 {R}eporter {K}nock-in {M}ouse}",
       Journal="J. Immunol.",
       Year="2015",
       Volume="194",
       Number="4",
       Pages="1841--1855",
       Month="Feb"
  • Karsten, C. M. and Kohl, J.: A bone to pick with Fc gamma receptors Ann Transl Med, vol. 3, no. 15, pp. 218, p, 2015
    BibTeX Pubmed Auszeichnung
    @Article{pmid26488014,
       Author="Karsten, C. M.  and Kohl, J. ",
       Title="{{A} bone to pick with {F}c gamma receptors}",
       Journal="Ann Transl Med",
       Year="2015",
       Volume="3",
       Number="15",
       Pages="218",
       Month="Sep"
    }
    

2014

  • Bar, F., Foh, B., Pagel, R., Schroder, T., Schlichting, H., Hirose, M., Lemcke, S., Klinger, A., Konig, P., Karsten, C. M., Buning, J., Lehnert, H., Fellermann, K., Ibrahim, S. M. and Sina, C.: Carboxypeptidase E modulates intestinal immune homeostasis and protects against experimental colitis in mice PLoS ONE, vol. 9, no. 7, pp. 02347, 2014
    BibTeX Pubmed Auszeichnung
    @Article{pmid25051500,
       Author="Bar, F.  and Foh, B.  and Pagel, R.  and Schroder, T.  and Schlichting, H.  and Hirose, M.  and Lemcke, S.  and Klinger, A.  and Konig, P.  and Karsten, C. M.  and Buning, J.  and Lehnert, H.  and Fellermann, K.  and Ibrahim, S. M.  and Sina, C. ",
       Title="{{C}arboxypeptidase {E} modulates intestinal immune homeostasis and protects against experimental colitis in mice}",
       Journal="PLoS ONE",
       Year="2014",
       Volume="9",
       Number="7",
       Pages="e102347"

2012

  • Le Friec, G., Sheppard, D., Whiteman, P., Karsten, C. M., Shamoun, S. A., Laing, A., Bugeon, L., Dallman, M. J., Melchionna, T., Chillakuri, C., Smith, R. A., Drouet, C., Couzi, L., Fremeaux-Bacchi, V., Kohl, J., Waddington, S. N., McDonnell, J. M., Baker, A., Handford, P. A., Lea, S. M. and Kemper, C.: The CD46-Jagged1 interaction is critical for human T(H)1 immunity Nat. Immunol., t, 2012
    BibTeX Pubmed Auszeichnung
    @Article{pmid23086448,
       Author="Le Friec, G.  and Sheppard, D.  and Whiteman, P.  and Karsten, C. M.  and Shamoun, S. A.  and Laing, A.  and Bugeon, L.  and Dallman, M. J.  and Melchionna, T.  and Chillakuri, C.  and Smith, R. A.  and Drouet, C.  and Couzi, L.  and Fremeaux-Bacchi, V.  and Kohl, J.  and Waddington, S. N.  and McDonnell, J. M.  and Baker, A.  and Handford, P. A.  and Lea, S. M.  and Kemper, C. ",
       Title="{{T}he {C}{D}46-{J}agged1 interaction is critical for human {T}({H})1 immunity}",
       Journal="Nat. Immunol.",
       Year="2012",
       Pages=" ",
       Month="Oct"
    }
  • Karsten, C. M., Pandey, M. K., Figge, J., Kilchenstein, R., Taylor, P. R., Rosas, M., McDonald, J. U., Orr, S. J., Berger, M., Petzold, D., Blanchard, V., Winkler, A., Hess, C., Reid, D. M., Majoul, I. V., Strait, R. T., Harris, N. L., Kohl, G., Wex, E., Ludwig, R., Zillikens, D., Nimmerjahn, F., Finkelman, F. D., Brown, G. D., Ehlers, M. and Kohl, J.: Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1 Nat. Med., g, 2012
    BibTeX Pubmed Auszeichnung
    @Article{pmid22922409,
       Author="Karsten, C. M.  and Pandey, M. K.  and Figge, J.  and Kilchenstein, R.  and Taylor, P. R.  and Rosas, M.  and McDonald, J. U.  and Orr, S. J.  and Berger, M.  and Petzold, D.  and Blanchard, V.  and Winkler, A.  and Hess, C.  and Reid, D. M.  and Majoul, I. V.  and Strait, R. T.  and Harris, N. L.  and Kohl, G.  and Wex, E.  and Ludwig, R.  and Zillikens, D.  and Nimmerjahn, F.  and Finkelman, F. D.  and Brown, G. D.  and Ehlers, M.  and Kohl, J. ",
       Title="{{A}nti-inflammatory activity of {I}g{G}1 mediated by {F}c galactosylation and association of {F}cγ{R}{I}{I}{B} and dectin-1}",
       Journal="Nat. Med.",
       Year="2012",
       Pages=" ",
       Month="Aug"
    }