Prof. Dr. rer. nat. Tobias Restle


Institute for molecular medicine
University of Lübeck
Ratzeburger Allee 160
23538 Lübeck

Email:
Phone:
+49 451 500 50805
Fax:
+49 451 500 50804

Publications

2016

  • Willkomm, S., Deerberg, A., Heidemann, J., Flugge, F., Meine, J., Hu, R., Kretschmer-Kazemi Far, R. and Restle, T.: Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro PLoS ONE, vol. 11, no. 1, pp. 146814, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid26784517,
       Author="Willkomm, S.  and Deerberg, A.  and Heidemann, J.  and Flugge, F.  and Meine, J.  and Hu, R.  and Kretschmer-Kazemi Far, R.  and Restle, T. ",
       Title="{{R}ecombinant h{T}{R}{B}{P} and h{P}{A}{C}{T} {M}odulate h{A}go2-{C}atalyzed si{R}{N}{A}-{M}ediated {T}arget {R}{N}{A} {C}leavage {I}n {V}itro}",
       Journal="PLoS ONE",
       Year="2016",
       Volume="11",
       Number="1",
       Pages="e0146814"
    }
    
  • Kalia, M., Willkomm, S., Claussen, J. C., Restle, T. and Bonvin, A. M.: Novel Insights into Guide RNA 5`-Nucleoside/Tide Binding by Human Argonaute 2 Int J Mol Sci, vol. 17, no. 1, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid26712743,
       Author="Kalia, M.  and Willkomm, S.  and Claussen, J. C.  and Restle, T.  and Bonvin, A. M. ",
       Title="{{N}ovel {I}nsights into {G}uide {R}{N}{A} 5'-{N}ucleoside/{T}ide {B}inding by {H}uman {A}rgonaute 2}",
       Journal="Int J Mol Sci",
       Year="2016",
       Volume="17",
       Number="1",
       Pages=" "
    }
  • Sharma, K. K., Przybilla, F., Restle, T., Godet, J. and Mely, Y.: FRET-based assay to screen inhibitors of HIV-1 reverse transcriptase and nucleocapsid protein Nucleic Acids Res., vol. 44, no. 8, pp. e74, y, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid26762982,
       Author="Sharma, K. K.  and Przybilla, F.  and Restle, T.  and Godet, J.  and Mely, Y. ",
       Title="{{F}{R}{E}{T}-based assay to screen inhibitors of {H}{I}{V}-1 reverse transcriptase and nucleocapsid protein}",
       Journal="Nucleic Acids Res.",
       Year="2016",
       Volume="44",
       Number="8",
       Pages="e74",
       Month="May"
    }
  • Gupta, Y., Moller, S., Witte, M., Belheouane, M., Sezin, T., Hirose, M., Vorobyev, A., Niesar, F., Bischof, J., Ludwig, R. J., Zillikens, D., Sadik, C. D., Restle, T., Hasler, R., Baines, J. F. and Ibrahim, S. M.: Dissecting genetics of cutaneous miRNA in a mouse model of an autoimmune blistering disease BMC Genomics, vol. 17, pp. 2, 2016
    BibTeX Pubmed Auszeichnung
    @Article{pmid26879236,
       Author="Gupta, Y.  and Moller, S.  and Witte, M.  and Belheouane, M.  and Sezin, T.  and Hirose, M.  and Vorobyev, A.  and Niesar, F.  and Bischof, J.  and Ludwig, R. J.  and Zillikens, D.  and Sadik, C. D.  and Restle, T.  and Hasler, R.  and Baines, J. F.  and Ibrahim, S. M. ",
       Title="{{D}issecting genetics of cutaneous mi{R}{N}{A} in a mouse model of an autoimmune blistering disease}",
       Journal="BMC Genomics",
       Year="2016",
       Volume="17",
       Pages="112"
    }

2015

  • Dornseifer, S., Willkomm, S., Far, R. K., Liebschwager, J., Beltsiou, F., Frank, K., Laufer, S. D., Martinetz, T., Sczakiel, G., Claussen, J. C. and Restle, T.: RNAi revised-target mRNA-dependent enhancement of gene silencing Nucleic Acids Res., vol. 43, no. 22, pp. 10623-10632, c, 2015
    BibTeX Pubmed Auszeichnung
    @Article{pmid26578554,
       Author="Dornseifer, S.  and Willkomm, S.  and Far, R. K.  and Liebschwager, J.  and Beltsiou, F.  and Frank, K.  and Laufer, S. D.  and Martinetz, T.  and Sczakiel, G.  and Claussen, J. C.  and Restle, T. ",
       Title="{{R}{N}{A}i revised--target m{R}{N}{A}-dependent enhancement of gene silencing}",
       Journal="Nucleic Acids Res.",
       Year="2015",
       Volume="43",
       Number="22",
       Pages="10623--10632",
       Month="Dec"
    }
  • Sharma, K. K., Przybilla, F., Restle, T., Boudier, C., Godet, J. and Mely, Y.: Reverse Transcriptase in Action: FRET-Based Assay for Monitoring Flipping and Polymerase Activity in Real Time Anal. Chem., vol. 87, no. 15, pp. 7690-7697, g, 2015
    BibTeX Pubmed Auszeichnung
    @Article{pmid26125954,
       Author="Sharma, K. K.  and Przybilla, F.  and Restle, T.  and Boudier, C.  and Godet, J.  and Mely, Y. ",
       Title="{{R}everse {T}ranscriptase in {A}ction: {F}{R}{E}{T}-{B}ased {A}ssay for {M}onitoring {F}lipping and {P}olymerase {A}ctivity in {R}eal {T}ime}",
       Journal="Anal. Chem.",
       Year="2015",
       Volume="87",
       Number="15",
       Pages="7690--7697",
       Month="Aug"
    }
    
  • Willkomm, S. and Restle, T.: Conformational Dynamics of Ago-Mediated Silencing Processes Int J Mol Sci, vol. 16, no. 7, pp. 769-14785, 2015
    BibTeX Pubmed Auszeichnung
    @Article{pmid26140373,
       Author="Willkomm, S.  and Restle, T. ",
       Title="{{C}onformational {D}ynamics of {A}go-{M}ediated {S}ilencing {P}rocesses}",
       Journal="Int J Mol Sci",
       Year="2015",
       Volume="16",
       Number="7",
       Pages="14769--14785"
    }
    

2014

  • Gupta, Y., Witte, M., Moller, S., Ludwig, R. J., Restle, T., Zillikens, D. and Ibrahim, S. M.: ptRNApred: computational identification and classification of post-transcriptional RNA Nucleic Acids Res., vol. 42, no. 22, pp. e167, c, 2014
    BibTeX Pubmed Auszeichnung
    @Article{pmid25303994,
       Author="Gupta, Y.  and Witte, M.  and Moller, S.  and Ludwig, R. J.  and Restle, T.  and Zillikens, D.  and Ibrahim, S. M. ",
       Title="{pt{R}{N}{A}pred: computational identification and classification of post-transcriptional {R}{N}{A}}",
       Journal="Nucleic Acids Res.",
       Year="2014",
       Volume="42",
       Number="22",
       Pages="e167",
       Month="Dec"
    }
    

2013

  • Deerberg, A., Willkomm, S. and Restle, T.: Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein Proc. Natl. Acad. Sci. U.S.A., vol. 110, no. 44, pp. 17850-17855, t, 2013
    BibTeX Pubmed Auszeichnung
    @Article{pmid24101500,
       Author="Deerberg, A.  and Willkomm, S.  and Restle, T. ",
       Title="{{M}inimal mechanistic model of si{R}{N}{A}-dependent target {R}{N}{A} slicing by recombinant human {A}rgonaute 2 protein}",
       Journal="Proc. Natl. Acad. Sci. U.S.A.",
       Year="2013",
       Volume="110",
       Number="44",
       Pages="17850--17855",
       Month="Oct"
  • Lyonnais, S., Gorelick, R. J., Heniche-Boukhalfa, F., Bouaziz, S., Parissi, V., Mouscadet, J. F., Restle, T., Gatell, J. M., Le Cam, E. and Mirambeau, G.: A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA Virus Res., vol. 171, no. 2, pp. 287-303, b, 2013
    BibTeX Pubmed Auszeichnung
    @Article{pmid23017337,
       Author="Lyonnais, S.  and Gorelick, R. J.  and Heniche-Boukhalfa, F.  and Bouaziz, S.  and Parissi, V.  and Mouscadet, J. F.  and Restle, T.  and Gatell, J. M.  and Le Cam, E.  and Mirambeau, G. ",
       Title="{{A} protein ballet around the viral genome orchestrated by {H}{I}{V}-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed {R}{N}{A} to {V}pr-bridged {D}{N}{A}}",
       Journal="Virus Res.",
       Year="2013",
       Volume="171",
       Number="2",
       Pages="287--303",
       Month="Feb"